49ers head coach Kyle Shanahan employs an offensive system that tends to get the most out of his players, especially his quarterbacks. It has played a role in Jones' apparent revival, and perhaps O'Connell, who was named second-team All-Big-Ten twice while at Purdue University, can be a nice insurance option for them in 2026.

San Francisco 49ers head coach Kyle Shanahan has plenty of kind words to say about Carolina Panthers rookie wide receiver Tetairoa McMillan leading into their teams' upcoming Monday Night Football matchup,

The NFL season continues in Week 11 when the San Francisco 49ers host the Arizona Cardinals on Sunday. Start time, how to watch, streaming and NFL schedule.

The San Francisco 49ers have some talent along their defensive line, but they could use more, and that could come early in the 2026 NFL draft.

It would’ve been impossible to imagine San Francisco 49ers running back Christian McCaffrey being on the verge of a different kind of greatness this time last year.

Mike Florio teases the idea of the Vikings going after quarterback Mac Jones after his resurgence with the 49ers.

Mike Florio and Chris Simms look ahead to MNF, where a sneaky-fun Panthers team heads across the country to play the 49ers, who are slowly getting healthier and finding a rhythm on offense.

San Francisco 49ers quarterback Brock Purdy (13) passes as Arizona Cardinals cornerback Max Melton (16) applies pressure during the second half of an NFL football game in Glendale, Ariz., Sunday, Nov. 16, 2025. Credit: AP/Ross D. Franklin Turnover differential: Panthers minus-4; 49ers minus-5.