An octopus-shaped nanomachine hijacks tumor ATP leakage to power a self-amplifying cycle of membrane damage, drug delivery, and metabolic collapse in cancer cells.

Cancer cells undergo physically constraining processes, such as intravasation, extravasation, and tissue infiltration, that lead to acute mechanical stress. How mechanical confinement rewires the ...

The proton gradients that power respiration are as universal as the genetic code itself, giving an insight into the origin of life and the singular origin of complexity. Why do virtually all cells ...

RIKEN biophysicists have uncovered how a crucial cellular motor, F1-ATPase, generates mechanical force using advanced ...

The prevalence of kidney disease has been increasing in Japan, with it now affecting one in eight adults, but developing effective treatment remains a challenge. The kidneys are among the most ...

When cancer cells are physically squeezed, they mount an instant, high-energy defense by rushing mitochondria to the cell nucleus, unleashing a surge of ATP that fuels DNA repair and survival. This ...

A single-atom nanozyme mimicking cytochrome c oxidase restores mitochondrial energy production in stem cells, shifting their ...

T cells are not able to create their cellular energy, called adenosine triphosphate or ATP, when they are inside a solid tumor. Now, researchers led by UNC Lineberger Comprehensive Cancer Center may ...

“[...] our current work has provided a novel strategy to enrich for a sub-population of cancer cells, with high basal levels of mitophagy.” Mitophagy is a ...