Cell motility and adhesion are fundamental processes that underpin embryonic development, immune surveillance, wound healing and tumour invasion. At their core lies a dynamic interplay between ...

Focal adhesion kinase (FAK) is a central regulator of how cells sense and respond to their surroundings. Situated at integrin-based adhesions, FAK transmits signals from the extracellular matrix and ...

Researchers at the Federal University of São Paulo (UNIFESP) in Brazil have identified a molecule on the surface of cells that could be a promising therapeutic target against cancer. This molecule ...

A new study shows how an anticancer drug triggers an 'outside in' signal that gets it sucked into a cancer cell. The work reveals a new signaling mechanism that could be exploited for delivering other ...

The cells of all animals—including humans—are characterized by their ability to adhere particularly well to surfaces in their environment. This mechanically stable adhesion enables the development of ...

Cornell researchers have uncovered a built-in molecular "gate" that controls the production of the molecule nitric oxide, a crucial signaling molecule throughout biology that in humans helps regulate ...