With every bite of food we take, our intestinal immune system must make a big decision. Tasked with defending us from foreign pathogens, these exquisitely sensitive cells somehow distinguish friend ...

A miniaturized, biomimetic model of the human intestine has successfully reproduced long-term enterovirus A71 (EV-A71) ...

Dendritic cells (DCs) are pivotal sentinels at the intestinal interface, orchestrating a balance between immune defence and tolerance. In the healthy gut, specialised DC subsets sample luminal ...

Researchers found that a small population of immune cells in the mouse intestine prevents allergic responses to food, suggesting that targeting such cells therapeutically could potentially lead to a ...

Beyond bacteria, fungi and archaea are emerging as powerful regulators of digestion, immunity, and disease risk, revealing ...

Crypt-base-columnar cells are continuously dividing intestinal stem cells that generate IECs, which are composed by distinct specialised cell types that play different functions: Enterocytes (in the ...

The intestinal immune system can usually recognize friend from foe. But for approximately 30 million Americans with food allergies—including four million children—immune cells mistakenly identify food ...

The novel oral polio vaccine type 2 (nOPV2) induced intestinal mucosal immune responses comparable to those induced by the traditional Sabin monovalent oral polio vaccine type 2 (mOPV2) across ...

A genetics‑guided small molecule called compound 6 gently turns down an overactive immune pathway (CARD9), offering a more precise, durable, and potentially safer treatment strategy for Crohn’s ...

Gastrointestinal (GI) malignancies—including esophageal, gastric, colorectal, hepatic, and pancreatic cancers—constitute a major global health burden and ...