A major AFC matchup takes place on Thursday night in Week 12 of the 2025 NFL season, as the Houston Texans (5-5) host the Buffalo Bills (7-3).  Both of these te

NFL Week 12 odds, picks, predictions, TV channel, streaming information for the Thursday Night Football game between Buffalo Bills and Houston Texans.

S omething remarkable happened in the Buffalo Bills victory over the Tampa Bay Buccaneers on Sunday. Sure, Josh Allen accounted for six touchdowns. But the Bills finally didn't lose a single defensive players due to injury.

Fans in the Buffalo TV market can watch the game on WKBW Channel 7. Coverage starts at 7:30 p.m. with a special pregame edition of Leading The Charge.

Aug 9, 2024; Pittsburgh, Pennsylvania, USA; Houston Texans helmets sit on an equipment trunk during the second quarter against the Pittsburgh Steelers at Acrisure Stadium. Mandatory Credit: Charles LeClaire-USA TODAY Sports © Charles LeClaire, Charles LeClaire-USA TODAY Sports

Coming off a 44-point offensive explosion, the Bills now face the Texans' league-best defense. Here's a look ahead to the Thursday night game.

In four of Houston's five losses, Texans had a chance to win on final possession but came up short. After two rallies, confidence is back.

Mills led three touchdown drives in the 4th quarter to bring the Texans back from 19 points down for the victory.

The Buffalo Bills and Tampa Bay Buccaneers played one of the wildest games of Week 11, and it ended with the two teams combining to make some NFL history. The game ended with the Bills topping the Bucs, 44-32, a score that had never happened before in the 106-year history of the NFL.

Kyle Madson of Niners Wire takes Cardinals fans behind enemy lines before the Week 11 Cardinals vs. 49ers showdown.