Efficient T-cell engineering is crucial for the success of CAR T-cell therapy research, but it requires multiple labor-intensive steps, including T-cell isolation, activation, and transduction.

Immunotherapy has revolutionized the way physicians treat patients. Previously, chemotherapy was the standard-of-care with the goal to eliminate tumor cell | Immunology ...

The orchestration of T cell activation is central to immune defence and self-tolerance. Recent advances have revealed that T cells integrate signals from their antigen receptors alongside a network of ...

Two studies suggest that T cells with stem-cell-like properties could work with antibody therapies to control HIV after a ...

Casitas B-lineage lymphoma-b (CBLB) is an E3 ubiquitin–protein ligase that functions as an intracellular checkpoint and master negative regulator of T‑cell and natural killer (NK) cell activation, ...

Selinexor-based regimens enhance T-cell activation in RRMM patients, without increasing inhibitory checkpoint molecules, indicating resistance is not due to T-cell exhaustion. Baseline protein ...

Blocking a single protein revs up T cells, boosting their energy reserves and helping them fight tumors longer in new mouse ...

Different subsets of γδ T cells display differential expression of immune checkpoint receptors (ICRs) and have distinct ...

Israel Institute of Technology Faculty of Biology have identified a unique mechanism involved in the aging of the immune system—along with a framework for enhancing its function in older individuals.

A clinical oncology research team at the LKS Faculty of Medicine, the University of Hong Kong (HKUMed), in collaboration with the US National Cancer Institute (NCI), has developed an innovative big ...

A new nanoparticle vaccine successfully prevented several aggressive cancers in mice, including pancreatic and melanoma. The ...