Recent evidence highlights the complex interplay between the central nervous system and hepatic drug-metabolising enzymes. In particular, the regulation of liver cytochrome P450 (CYP) enzymes by ...
Brain cytochrome P450 (CYP) enzymes represent a specialised set of metabolic proteins that, while less abundant than their hepatic counterparts, play an increasingly acknowledged role in the local ...
The cytochrome P450 (CYP) enzymes are a protein superfamily involved in the synthesis and metabolism of drugs, toxins and normal cellular components. The CYP family of enzymes have been identified in ...
To boost the statistical power to find Alzheimer’s genes, geneticists often use endophenotypes—measurable characteristics of the disease—in place of clinical diagnoses. Case in point: A genome-wide ...
New research from the University of Pittsburgh School of Pharmacy sheds light on the processes that lead to liver fibrosis and suggests a novel treatment approach for this common and serious condition ...
Effect of IL-6 and related mediators on resistance to abiraterone acetate (abi) and enzalutamide (enza) in patients with metastatic castration-resistant prostate cancer (mCRPC). This is an ASCO ...
New research from the University of Pittsburgh School of Pharmacy sheds light on the processes that lead to liver fibrosis and suggests a novel treatment approach for this common and serious condition ...