The well-studied NF-κB signaling system is a key mediator of the inflammatory response. Large-scale sequencing studies in ...

Arabidopsis genome encodes approximately 60 putative MAPKKKs, 10 MAPKKs, and 20 MAPKs (MAPK‐Group, 2002).MAPK cascades have been shown to regulate diverse aspects of plant biology, including plant ...

In this study, we generated new in-vivo treatment models of Brca1- and Bard1-mutant breast cancer that recapitulate the striking response to PARPi, acquired resistance, and recurrence that is observed ...

DDX5 is the most abundant RNA helicase and is aberrantly expressed in most malignant tumors, where it participates in transcriptional regulation, differentiation, metastasis, and regulation of various ...

Astrocytes are generated from radial glial cells (RGCs) in the ventricular zone during brain development (Kriegstein and Alvarez-Buylla, 2009; Lin et al, 2021).In the dorsal neocortex, RGCs express ...

Perturbations in the proteostasis machinery play an important role in modulating aging-associated pathways (Balch et al, 2008; Hipp et al, 2019; Jayaraj et al, 2020; Klaips et al, 2018; Labbadia and ...

TP53-mutant acute myeloid leukemia (AML) and myelodysplastic neoplasms (MDS) are characterized by chemotherapy resistance and represent an unmet clinical need.Chimeric antigen receptor (CAR) T-cells ...

The bacterial homolog DgoT (from E. coli) transports negatively charged galactonate in symport with more than one proton and, thus, differs from mammalian SLC17s in both its main substrate and ...

Recently, we were able to show that both SARS-CoV-2 infection and mRNA vaccination prime human monocyte-derived macrophages for potent secretion of pro-inflammatory cytokines following restimulation ...

To address this phenomenon, we previously conducted comprehensive analyses of inflammation-related mRNAs and microRNAs (miRNAs) by comparing PU.1-deficient (PU.1 −/−) mice, which lack neutrophils, ...

In this study, we set out to explore the growth adaptation observed upon loss of ASCT2, expanding the HCC1806 data across four additional breast cancer cell lines, including both TNBC (glutamine ...

Recessive gene mutations underlie many developmental disorders and often lead to disabling neurological problems. Here, we report identification of a homozygous c.170G>A (p.Cys57Tyr or C57Y) mutation ...