RNA degradation is an essential process for maintaining cellular homeostasis, regulating both the quantity and quality of RNAs in the eukaryotic cell. RNA degradation typically occurs by exonuclease ...

This study identifies 53BP1 as an interaction partner of GMCL1 (a likely CUL3 substrate receptor). The study seeks to link this finding to regulation of the mitotic surveillance pathway and paclitaxel ...

Complex traits are influenced by genes and the environment, but especially the latter is difficult to pin down. This important study uses C. elegans to demonstrate that non-genetic differences in gene ...