Scientists engineered stem cells with “interrupted” CAG repeats to break up the toxic stretch. This may stop expansion, and could improve problems in cells that model Huntington’s disease. This study ...
CAG repeats can get longer over time as the HD gene is used, like the growing potholes and cracks in an old road. New ...
POINT-HD has begun dosing its first participants with the drug RG6496, marking an early but important step for a new selective huntingtin-lowering approach.
By setting up both reactions side by side in a test tube, the team revealed a literal tug-of-war between two DNA-repair pathways acting on the same HTT repeat. Which side wins likely determines ...
UniQure received FDA’s meeting minutes on AMT-130. While there were no new updates, the community’s response has been powerful, with 34K+ petition signatures & unified advocacy from major HD orgs.
Imagine a busy clothing factory. Proteins are like newly sewn shirts coming off the machines. They’re floppy, wrinkled, and can create a giant mess if they’re left unfolded. Normally, the cellular ...
When it comes to thinking about the effects of Huntington’s disease (HD), most people automatically start to think about the brain due to the severe symptoms caused by the breakdown of brain cells. It ...
Living with HD is challenging enough, but depression and anxiety, two of the most common psychiatric symptoms in HD, can make everything exponentially harder. Imagine trying to navigate your daily ...
Welcome back to the HDBuzz monthly research roundup! November was a busy month, with new developments in everything from gene therapy and stem cells to DNA repair, genetic modifiers, and protein ...
Piere studied Biology at Cayetano Heredia University in Lima (Peru), then obtained a PhD in Biophysics at UC Berkeley in the Bustamante Lab, specializing in molecular motors and single-molecule ...
In plain language. Written by scientists. For the global HD community. A new study from Switzerland sheds light on how the CAG repeat number in the Huntington’s disease gene can grow or shrink inside ...
In plain language. Written by scientists. For the global HD community. A new study from Switzerland sheds light on how the CAG repeat number in the Huntington’s disease gene can grow or shrink inside ...
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